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KMID : 0380219930260040312
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Journal of Biochemistry and Molecular Biology
1993 Volume.26 No. 4 p.312 ~ p.316
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Cloning and Analysis of a Rat cDNA Encoding a Nuclear Factor 1-like Protein(NF1-L)
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Hyekyung Jung
Kyu Jeong Ahn and Jong Sang Park
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Abstract
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NF1 is a family of transcription factors found in many kinds of animal. A cDNA (NF1-L2) partially overlapping with the previously known NF1-L cDNA was found in screening a rat liver cDNA library with a synthetic oligonucleotide probe. The clone NFl-L2 contained the missing 4 N-terminal amino acid residues including the Met translational initiator codon that were absent in the NF1-L cDNA sequence published previously. The clone NF1-L2 also included and extremely long 5` noncoding region in which multiple upstream ORFs were found. These short ORFs may be involved in translational regulation of NF1 ORF in some way. Results of Northern analysis indicate that the structure of NF1 transcripts in rat may be diverse and that several related genes may generate a large family of NF1 proteins.
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KEYWORD
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